How to protect against supply chain cyber risk with automation

By Joel Burleson-Davis, SVP Worldwide Engineering for Imprivata [ Join Cybersecurity Insiders ]
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The emphasis on securing supply chains against sophisticated cyberattacks has never been more pressing. The supply chain represents a vital artery for diverse industries, from healthcare to manufacturing, yet remains a prime vector for cyber infiltration.

In an era of increasingly interconnected business ecosystems, third-party vendors often hold the keys to sensitive systems and data without the security infrastructure that larger enterprises rely on. This imbalance reveals a significant vulnerability, with 56% of organizations reporting third-party data breaches, according to a survey conducted by Ponemon. In the majority of cases, excessive or unmanaged privileged access granted to third parties was the root cause.

With the rise of advanced threats like ransomware, supply chain poisoning, and AI-enhanced social engineering, it’s clear that organizations must adopt a more forward-looking, proactive defense strategy. The question isn’t whether a supply chain will be attacked; it’s how effectively it can be defended.

New era, new threats 

Modern attackers aren’t merely opportunistic—they’re strategic. Supply chain vulnerabilities offer attackers a less fortified entry point into larger, well-defended organizations. Cybercriminals know that breaching a smaller vendor with inadequate security measures can provide the access needed to disrupt an entire network of businesses; they also increasingly view third-party vendors as the weakest link in a security chain, exploiting their connections to enterprises for significant, often devastating breaches.

One prominent and growing threat is supply chain poisoning—a method where malicious actors compromise components or code during a product or service’s development or distribution phases. Once the poisoned asset enters the ecosystem, the impact multiplies, affecting numerous organizations reliant on the compromised software or hardware. This form of attack underscores the vulnerability in operational security and the software development lifecycle, where vetting and oversight can be inconsistent.

Modern cyber attacks are complex. Your defenses should be too. 

The convergence of AI-driven social engineering and traditional tactics has created a new breed of cyber threats. Today’s attackers can employ AI to conduct advanced phishing campaigns, utilizing deep fake technology to convincingly impersonate high-ranking executives or trusted third-party vendors. These AI-enhanced attacks bypass many human-level heuristics traditionally relied upon to detect fraud.

In a recent incident, we heard from a client that cybercriminals leveraged AI to synthesize a convincing replica of a senior executive’s voice. By mimicking tone, cadence, and speech patterns, they were able to deceive an organization’s help desk into nearly resetting multi-factor authentication (MFA) credentials—effectively granting the attackers full access to critical systems. This near-breach was only averted because of a stringent, albeit somewhat outdated, internal policy requiring in-person verification for such requests.

This incident illustrates the growing sophistication of AI-enhanced social engineering attacks, where even advanced security measures can be circumvented by well-crafted, highly personalized exploits. As AI continues to evolve, organizations must anticipate these more subtle, harder-to-detect threats, reinforcing their authentication protocols and building resilience against AI-generated deception.

In parallel, ransomware has evolved from a blunt-force tool into a more targeted and surgical weapon. Attackers now look for critical vulnerabilities in supply chains, recognizing that disrupting a single supplier can have far-reaching consequences for an entire ecosystem. The goal is no longer to extract a ransom from a singular entity but to leverage disruption across multiple organizations, compounding the financial and operational damage.

To stay ahead, organizations must recognize that AI isn’t only a tool for attackers—it’s also a powerful ally in defense. By leveraging AI and automation, companies can enhance their own security systems, building layers of protection that match the sophistication of today’s threats.

If organizations are serious about safeguarding their supply chains, they must also commit to upgrading status quo defenses. The complexity of modern cyber threats demands a strategic pivot toward leveraging AI and automation to bolster security at multiple levels. AI’s ability to ingest, process, and analyze vast quantities of data at speeds far beyond human capability makes it a natural fit for automating risk assessments and monitoring for anomalies within supply chain networks.

AI-enabled systems can continuously analyze data traffic and behavior patterns, identifying subtle deviations that might otherwise go unnoticed. They can also automate real-time threat detection and response, reducing dwell time and minimizing the window of opportunity for attackers.

And while AI and automation offer powerful tools for enhancing supply chain security, they’re not a silver bullet. Even the most sophisticated systems cannot fully compensate for the risk introduced by human error.

A stringent security posture is key

Beyond AI, strong third-party access management tools play a critical role in keeping intrusions at bay. Solutions like Vendor Privileged Access Management (VPAM) offer precise control over who can access sensitive information and for how long, making sure that only verified, authorized users get through. With tools that monitor, limit, and secure vendor access, organizations gain a vital layer of protection that addresses the unique risks posed by third-party interactions.

Employee education and awareness also remain critical components of any robust security strategy. After all, phishing attacks — many designed to compromise third-party vendors — still rely on human oversight failures to gain traction.

Employees, particularly those who interact with external vendors, must be trained to recognize the tactics used in social engineering schemes, understand the protocols for granting access to sensitive systems, and exercise skepticism in the face of unexpected or unusual requests.It’s essential to cultivate a security-first culture across the organization. Employees should understand that third-party vendors are not employees and, therefore, not held to the same security standards. Interactions with third-party vendors require heightened scrutiny.

Leadership must champion this mindset, demonstrating an unwavering commitment to security by integrating these practices into everyday operations. Clear communication, ongoing training, and a well-defined protocol for managing third-party access can reduce the likelihood of human errors, which often act as the entry points for more significant breaches.

As we consider the future, the role of AI-resistant security frameworks will become increasingly important. The very technologies that allow organizations to defend their supply chains can also be co-opted by attackers to enhance their methods. To mitigate this risk, companies must focus on strengthening identity verification and authentication processes.

Multi-factor authentication (MFA) and advanced AI algorithms can serve as a robust defense against AI-generated impersonation attempts. Biometric authentication (fingerprint scanning or facial recognition, for instance) adds a layer of security that is difficult to falsify using current AI techniques, safeguarding against deepfakes and other fraudulent activities.

What does the future of cybersecurity look like? 

Moving forward, we will likely see the evolution of self-managing systems that not only detect vulnerabilities and abnormalities but can automatically patch them without the need for human intervention. This kind of proactive cybersecurity, driven by continuous machine learning, will be critical in maintaining an edge over attackers who are constantly refining their methods. These innovations will allow for real-time adjustments in security postures, ensuring that the weakest link in a supply chain does not become the entry point for catastrophic breaches.

As cyber security threats become more and more sophisticated, organizations must reexamine their defenses, and the spotlight on supply chain security must remain bright. The interdependencies that define modern business make supply chains a critical asset and a significant risk. By integrating AI and automation with a strong culture of human vigilance, organizations can build a resilient supply chain that withstands today’s attacks and anticipates tomorrow’s threats.

The future of cybersecurity lies not in reacting to threats but in preventing them from ever taking hold, turning vulnerability into strength through intelligent, resilient and adaptable security.

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